File:1-s2.0-S0753332223006765-gr2.jpg
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Summary
| Description |
English: Fig. 2. Insight into biological and molecular pathways implicated in HDAC inhibition by panobinostat. Histone acetyl transferases (HAT) and histone deacetyl transferases compete with one another to control the acetylation status of histones (HDAC). By altering gene transcription and biological properties, panobinostat inhibits HDACs and causes hyperacetylation of histone and non-histone proteins, which exhibits anticancer effects by reducing cell proliferation and survival while increasing cell cycle arrest and differentiation, inducing apoptosis, and enhancing immune response. |
| Date | |
| Source | https://pubmed.ncbi.nlm.nih.gov/37224752/ |
| Author | Nasreddine El Omari , Saad Bakrim , Asaad Khalid , Ashraf N Abdalla , Waleed Hassan Almalki , Learn-Han Lee , Chrismawan Ardianto , Long Chiau Ming , Abdelhakim Bouyahya |
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English: This file is licensed CC BY-NC-ND 4.0
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 22:26, 4 December 2023 | | 678 × 383 (44 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Nasreddine El Omari , Saad Bakrim , Asaad Khalid , Ashraf N Abdalla , Waleed Hassan Almalki , Learn-Han Lee , Chrismawan Ardianto , Long Chiau Ming , Abdelhakim Bouyahya from https://pubmed.ncbi.nlm.nih.gov/37224752/ with UploadWizard |
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