File:40120 2016 40 Fig1 HTML.jpg
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Summary
| Description |
English: TTR amyloidogenesis and TTR stabilization by tafamidis (a). The TTR amyloidogenic cascade. TTR is a tetrameric protein that can be destabilized by mutations in TTR, resulting in its dissociation into monomers that rapidly misfold and misassemble into aggregates, including pathologic structures associated with TTR amyloidosis [23, 40–45]. Also shown are the molecular structure of tafamidis (b) and the co-crystal structure of tafamidis (black, ball-and-stick) bound to a TTR tetramer (ribbon) (c). TTR transthyretin |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919130/ |
| Author | Coelho T, Merlini G, Bulawa CE, Fleming JA, Judge DP, Kelly JW, Maurer MS, Planté-Bordeneuve V, Labaudinière R, Mundayat R, Riley S, Lombardo I, Huertas P. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 21:30, 20 January 2024 | | 767 × 973 (137 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Coelho T, Merlini G, Bulawa CE, Fleming JA, Judge DP, Kelly JW, Maurer MS, Planté-Bordeneuve V, Labaudinière R, Mundayat R, Riley S, Lombardo I, Huertas P. from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919130/ with UploadWizard |
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