File:Abdominal wall metastasis from colorectal carcinoma (Radiopaedia 31016-31722 H&E 1).png

Summary:

• Radiopaedia case ID: 31016
• Image ID: 8304813
• Plane projection: H&E
• Study description: Core biopsy left groin mass.
• Study findings: Serial sections of the core biopsies show infiltration of fibrous connective tissue by poorly differentiated adenocarcinoma. This consists of irregularly shaped glandular structures lined by markedly pleomorphic cuboidal and columnar epithelial cells. These have irregularly shaped hyperchromatic and vesicular nuclei with a variable amount of pale cytoplasm. Solid aggregates of similar appearing atypical cells are also noted. Frequent mitotic figures are identified and there are foci of tumor necrosis. The features are consistent with an origin from colorectum. DIAGNOSIS: "Left groin mass core biopsies": Infiltration of fibrous tissue by poorly differentiated adenocarcinoma with features consistent with an origin from colorectum. Immunohistochemistry shows strong nuclear staining for CDX2 in tumor cells and strong cytoplasmic staining for carcinoembryonic antigen (CEA) and cytokeratin CK20. No staining for TTF-1 or cytokeratin CK7 is seen in tumor cells. This profile indicates an origin of tumor from colorectum.
• Modality: Pathology
• System: Gastrointestinal
• Findings: FDG avid node left external iliac chain.
• Published: 20th Sep 2014
• Source: https://radiopaedia.org/cases/abdominal-wall-metastasis-from-colorectal-carcinoma
• Author: Jan Frank Gerstenmaier
• Permission: http://creativecommons.org/licenses/by-nc-sa/3.0/

Licensing:

CC-BY-NC-SA-3.0