File:Aging-12-103095-g002.jpg
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English: Molecular mechanisms of metformin-associated lactic acidosis (MALA). Metformin (1) inhibits mitochondrial respiratory chain complex I, reducing Krebs cycle flux and shifting metabolism toward glycolysis, increasing the pyruvate level; (2) partly inhibits gluconeogenesis through the AMPK pathway, further contributing to pyruvate accumulation and increasing the conversion of accumulated pyruvate to lactate; and (3) inhibits mGPD, blocking the G3P pathway and altering the cytoplasmic redox state, inhibiting the conversion of lactate to pyruvate, resulting in MALA. (AMPK, AMP-activated protein kinase; LKB1, liver kinase B1; G3P, glycerol-3-phosphate; DHAP, dihydroxyacetone phosphate; mGPD, mitochondrial glycerophosphate dehydrogenase; cGPD, cytosolic glycerophosphate dehydrogenase). |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244070/ |
Author | Qingjun Pan, Xing Lu, Chunfei Zhao, Shuzhen Liao, Xiaoqun Chen, Fengbiao Guo, Chen Yang,Hua-feng Liu |
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English: This file is licensed CC BY-NC 3.0
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current | 21:19, 10 May 2023 | 762 × 640 (128 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Qingjun Pan, Xing Lu, Chunfei Zhao, Shuzhen Liao, Xiaoqun Chen, Fengbiao Guo, Chen Yang,Hua-feng Liu from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244070/ with UploadWizard |
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