File:Anaplastic astrocytoma (Radiopaedia 57768-65221 C 1).png

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Anaplastic_astrocytoma_(Radiopaedia_57768-65221_C_1).png ‎(771 × 577 pixels, file size: 863 KB, MIME type: image/png)

Summary:

Description
  • Radiopaedia case ID: 57768
  • Image ID: 35623094
  • Study description: Pathology
  • Study findings: MICROSCOPIC DESCRIPTION: 1-5. Sections show fragments of a moderately hypercellular glioma with prominent background edema. The tumor cells demonstrate variable morphology with specimens 1-3 showing moderate nuclear and cellular pleomorphism with rounded nuclei and perinuclear halos. Specimens 4-5 show increased tumor pleomorphism with scattered bizarre multinucleated tumor cells and frequent mitotic figures (up to 12 per 10hpf). There is prominent perivascular lymphocytic cuffing. No microvascular proliferation or palisaded tumor necrosis is seen. Immunohistochemistry results show tumor cells stain: DIAGNOSIS: 1&2. Brain tissue, frontal tumor: IDH-1 mutated/ATRX wild type anaplastic glioma (WHO grade III), favoring astrocytoma. SUPPLEMENTARY REPORT FISH for chromosome 1p/19q deletion. 1p36 NO DELETION DETECTED. Images and report courtesy of the Royal Melbourne Hospital Pathology Department.
  • Modality: Pathology
  • System: Central Nervous System
  • Findings: There is a large, ill-defined region of white matter hypoattenuation extending from the left frontal lobe with the involvement of the posterior left frontal cortical grey matter at the vertex. No definite enhancing mass or lesion is identified. No calcification. The associated mass effect causes moderate compression of the frontal horn of the left lateral ventricle, frontal sulcal effacement and 5 mm rightward shift of the anterior falx cerebri. No hydrocephalus and no transtentorial herniation. No acute intracranial hemorrhage or extra-axial collection. No suspicious osseous lesions. The imaged paranasal sinuses and mastoid air cells are clear. Conclusion: Ill-defined hypodense left frontal lesion with no definite enhancement is nonetheless suspicious for a brain neoplasm, most likely a primary tumor and unlikely to be a metastasis given the patient's age and pattern of involvement.
Date Published: 4th Feb 2018
Source https://radiopaedia.org/cases/anaplastic-astrocytoma-8
Author Bruno Di Muzio
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)

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