File:Anaplastic oligodendroglioma (Radiopaedia 37667-39579 B 1).png

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Anaplastic_oligodendroglioma_(Radiopaedia_37667-39579_B_1).png ‎(720 × 540 pixels, file size: 935 KB, MIME type: image/png)

Summary:

Description
  • Radiopaedia case ID: 37667
  • Image ID: 13815496
  • Study findings: MICROSCOPIC DESCRIPTION: 1&2. The sections show fragments of a moderately hypercellular glial tumor. This consists predominantly of moderately pleomorphic oligodendroglial cells arranged in diffuse sheets. These are admixed with a population of reactive astrocytes. Moderate numbers of gliofibrillary ligodendrocytes are also seen. Moderate numbers of mitotic figures are identified (4/10 HPF). There is also microvascular proliferation with multilayering of atypical cells around vessel lumena. No necrosis is seen. IMMUNOHISTOCHEMISTRY: GFAP positive in reactive astrocytes and gliofibrillary oligodendrocytes; negative in tumlur oligodendrocytes. NogoA positive in tumor oligodendrocytes. ATRX positive (not mutated) IDH-1 R132H positive (mutated) MGMT negative (likely methylated) p53 negative in tumor oligodendrocytes Topoisomerase labeling index: Approximately 10% The features are of anaplastic oligodendroglioma (WHO grade III). DIAGNOSIS: 1&2. Right frontoparietal tumor: Anaplastic oligodendroglioma (WHO Grade III).
  • Modality: Pathology
  • System: Central Nervous System
  • Findings: Multifocal regions of cortical and subcortical T2/FLAIR hyperintensity are unchanged, and consistent with gliomatosis cerebri. No new enhancing lesion identified.
Date Published: 18th Jun 2015
Source https://radiopaedia.org/cases/anaplastic-oligodendroglioma-2
Author RMH Neuropathology
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)

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