File:Atypical parathyroid adenoma (Radiopaedia 46644-51128 20x H&E 1).jpg

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Summary:

Description
  • Radiopaedia case ID: 46644
  • Image ID: 23990436
  • Plane projection: 20x
  • Aux modality: H&E
  • Modality: Pathology
  • System: Head & Neck
  • Findings: Macroscopic and Microscopic Findings The specimen consists of a 1.20g, 12 mm well circumscribed tumor with peripheral fibrous capsule, composed of solid sheets of parathyroid epithelial oncocytic cells showing a vaguely organoid architecture without interspersed fat and showing a scant amount of peripheral normal appearing parathyroid gland.  Tumor cells are medium in size with rounded to ovoid nuclei and a moderate amount of oncocytic cytoplasm.  Thick, hyalinised fibrous stromal band traverse the lesion.  There is no tumor cell necrosis or hemorrhage.  There is no significant mitotic activity. 20x H&E: Low-power view shows sheets of parathyroid cells with a peripheral fibrous capsule and traversing hyalinised fibrous bands.  Normal surrounding parenchymal tissue is not seen in this section. 40x H&E: Medium-power view showing hyalinised bands, with epithelial cells displaying acinar architectural patterns which are subtly visible at this power. 100x H&E: Closer view. 200x H&E: This high power view highlights the bland, monomorphous and mitotically inactive appearance of the parathyroid cells. Immunohistochemistry A galectin-3 (Gal-3) immunohistochemical stain was performed, which was negative.
Date Published: 6th Feb 2017
Source https://radiopaedia.org/cases/atypical-parathyroid-adenoma
Author Mikkaela McCormack
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)

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current12:42, 3 June 2021Thumbnail for version as of 12:42, 3 June 20212,502 × 1,818 (1.79 MB)Fæ (talk | contribs)Radiopaedia project rID:46644 (batch #3248-1 A1)

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