File:Brain metastasis (sarcoma) (Radiopaedia 47576-52246 B 1).png

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Brain_metastasis_(sarcoma)_(Radiopaedia_47576-52246_B_1).png ‎(600 × 450 pixels, file size: 346 KB, MIME type: image/png)

Summary:

Description
  • Radiopaedia case ID: 47576
  • Image ID: 24745604
  • Study findings: MICROSCOPIC DESCRIPTION: Sections show a well circumscribed malignant spindle cell tumor with areas of geographic necrosis. Tumor cells contain elongate, oval vesicular nuclei, prominent nucleoli and abundant eosinophilic cytoplasm. Frequent mitoses are observed (>20/10hpf). Tumor cells are set within a dense sclerotic stroma. Scattered thin and thick walled blood vessels are present. No heterologous elements are seen. Immunohistochemical results show tumor cells stain: Positive: CD99, CKAE1/3, CAM5.2, EMA focal, CD31 focal, GATA3 focal, Calretinin focal Negative: CD34, BCL2, SMA, Desmin, cKIT, DOG1, S100, SOX10, WT1, p40, CK7, CK20, CDX2, TTF1, Mesothelin, AFP, HepPar1 DIAGNOSIS: Brain tumor: Undifferentiated malignant spindle cell tumor of uncertain lineage - further immunohistochemical stains to follow.
  • Modality: Pathology
  • System: Central Nervous System
  • Findings: Right frontal lobe circumscribed hyperdense mass showing vivid contrast enhancement and associated with surrounding vasogenic edema. No midline shift or cerebral herniations. Ventricles and basal cisterns are unremarkable. No skull lesions.
Date Published: 23rd Aug 2016
Source https://radiopaedia.org/cases/brain-metastasis-sarcoma-1
Author Bruno Di Muzio
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

Licensing:

Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)

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