File:Carcinoid tumor of the ileum with metastasis to orbit (Radiopaedia 28165-28426 B 1).jpg

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Carcinoid_tumor_of_the_ileum_with_metastasis_to_orbit_(Radiopaedia_28165-28426_B_1).jpg ‎(514 × 410 pixels, file size: 116 KB, MIME type: image/jpeg)

Summary:

Description
  • Radiopaedia case ID: 28165
  • Image ID: 6220482
  • Plane projection: H&E
  • Study description: Histology (orbit)
  • Study findings: MACROSCOPIC DESCRIPTION: An irregular grey tan nodule, 20x10x10mm. Inked blue and serially sectioned. MICROSCOPIC DESCRIPTION: Paraffin sections show a densely hypercellular tumor. This consists of cells with uniform round and oval vesicular nuclei with conspicuous nucleoli and a small amount of pale cytoplasm. These are arranged in irregularly shaped solid islands which are haphazardly dispersed in a dense fibrous stroma. A palisaded arrangement of tumor cells at the periphery of these islands is noted. Occasional mitoses are identified. No necrosis is seen. Immunohistochemistry shows strong staining in tumor cells for pancytokeratin AE1/AE3, BerEp4, synaptophysin, CDX2 and neuron specific enolase (NSE) and moderate staining for CD56. No staining for S-100 protein or TTF-1 is seen in tumor cells. The features are of carcinoid tumor. The topoisomerase labeling index is approximately 3% FINAL DIAGNOSIS:Right orbital tumor: Carcinoid tumor Primary carcinoid tumors of the orbit are rare. Those that have been reported have usually had a dural attachment. Metastatic carcinoid tumors usually have atypical features which this tumor lacks. Primary sites that should be excluded however include lung, cecum/appendix, small bowel and pancreas.
  • Modality: Pathology
  • System: Oncology
  • Findings: A well circumscribed right orbital mass demonstrating homogeneous contrast enhancement is seen. It displaces the medial rectus inferiorly and the superior rectus laterally. The optic nerve is displaced inferolaterally.
Date Published: 13th Mar 2014
Source https://radiopaedia.org/cases/carcinoid-tumour-of-the-ileum-with-metastasis-to-orbit
Author RMH Neuropathology
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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