File:Cardiac tumor - undifferentiated pleomorphic sarcoma (Radiopaedia 45844-50141 B 1).png

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Summary:

Description
  • Radiopaedia case ID: 45844
  • Image ID: 23291707
  • Study findings: The patient went on to have surgery. Histology MICROSCOPIC DESCRIPTION: The sections show a malignant pleomorphic tumor. The tumor forms nests and cords. No glandular structures are seen. No anastomosing vascular channels are noted. The tumor cells are mainly epithelioid in appearance with enlarged pleomorphic nuclei, prominent nucleoli and scanty ill-defined cytoplasm. Some cells have intranuclear pseudoinclusions. No brown cytoplasmic pigment is seen. Mitoses are inconspicuous. There is no evidence of lymphovascular invasion. Occasional eosinophils are noted in the background. The tumor cells show positive staining for CD31 (histiocytic and vascular marker) and CD99 with some possible faint CD10 reactivity. There is patchy granular cytoplasmic staining for melan-A, of uncertain significance. All other melanocytic markers are negative (S-100, SOX-10, HMB-45, Tyrosinase). The Ki-67 index is about 20%. CAM5.2, AE1/3, CK7, CK20, CDX-2, TTF-1, p40, calretinin, CD34, c-kit, desmin, actin, myogenin, CD3, CD15, CD20, CD30, CD43, CD68 and ALK-1 are also negative. Carcinoma, melanoma and lymphoma have been excluded. The features are consistent with undifferentiated pleomorphic sarcoma, as a diagnosis of exclusion. FINAL DIAGNOSIS: Undifferentiated pleomorphic sarcoma.
  • Modality: Pathology
  • System: Chest
  • Findings: PA and lateral chest x-ray demonstrate enlargement of the cardiac silhouette. No effusions or masses.
Date Published: 28th Mar 2018
Source https://radiopaedia.org/cases/cardiac-tumour-undifferentiated-pleomorphic-sarcoma
Author Frank Gaillard
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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current16:25, 3 July 2021Thumbnail for version as of 16:25, 3 July 20212,400 × 1,800 (6.48 MB)Fæ (talk | contribs)Radiopaedia project rID:45844 (batch #6080-2 B1)

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