File:Chondrosarcoma (clivus) (Radiopaedia 46895-51462 E 1).png

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Summary:

Description
  • Radiopaedia case ID: 46895
  • Image ID: 24216022
  • Aux modality: H&E
  • Study findings: The biopsies show a chondroid neoplasm. It is mildly hypercellular, containing lobules of cartilage. The chondrocytes have focal mild nuclear enlargement and hyperchromasia. Occasional binucleated forms are seen. There are no mitoses or necrosis. Some of the cartilage are surrounded by host bone. An invasive growth pattern is noted although no definite invasion through the bone is seen. The lesional cells are S-100 and M2A positive, confirming chondroid differentiation. They are CAM5.2 negative, excluding chordoma. DIAGNOSIS: Grade 1 chondrosarcoma.
  • Modality: Pathology
  • System: Central Nervous System
  • Findings: A markedly T2 hyperintense lobulated mass arising from the right aspect of the clivus corresponding to a relatively homogeneous T1 iso/ hypointensity with heterogeneous enhancement post contrast is noted. No associated diffusion restriction. The mass exerts mass effect on the right side of the pons, however the 4th ventricle and cerebral aqueduct remain capacious and there is no hydrocephalus. Adjacent flow void within the right petrous/cavernous ICA is preserved. No other intracranial or skull base lesion seen. Conclusion: Marked T2 hyperintensity can be seen with either chondroid lesions or chordoma. Less likely differentials include an ecchordosis physaliphora, cavernous sinus hemangioma and least likely (given morphology) a schwannoma. Overall features favor a chondroid series tumor (including chondrosarcoma), although chordoma can occur off midline and evoke bony erosion/sequestration which can mimic a similar pattern of bony change. Further assessment with CT to evaluate matrix calcification/ossification and bony margins is recommended.
Date Published: 24th Jul 2016
Source https://radiopaedia.org/cases/chondrosarcoma-clivus
Author Frank Gaillard
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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current19:42, 13 August 2021Thumbnail for version as of 19:42, 13 August 20211,500 × 1,125 (3.23 MB)Fæ (talk | contribs)Radiopaedia project rID:46895 (batch #7781-5 E1)

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