File:Choroid plexus papilloma (Radiopaedia 34951-36444 Cytokeratin (CAM5.2) 1).jpg

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Summary:

Description
  • Radiopaedia case ID: 34951
  • Image ID: 11694182
  • Aux modality: Cytokeratin (CAM5.2)
  • Study findings: MICROSCOPIC DESCRIPTION: The sections show a moderately cellular papillary tumor. It has well-developed papillae with central fibrovascular cores. The lining cells have mildly enlarged and slightly clefted nuclei, generally small nucleoli and moderate amounts of clear foamy to pale eosinophilic cytoplasm. True ependymal rosettes or perivascular pseudorosettes are absent. Mitoses are inconspicuous. There are increased numbers of blood vessels at the tumor periphery but no microvascular proliferation is seen. No necrosis is identified. The tumor cells are diffusely CAM5.2 and focally GFAP positive. The topoisomerase index is 2%. They are transthyretin, synaptophysin, inhibin, EMA, CD10, Napsin-A, thyroglobulin and TTF-1 negative. The features are those of choroid plexus papilloma. DIAGNOSIS: Posterior fossa tumor: Choroid plexus papilloma (WHO Grade I).
  • Modality: Pathology
  • System: Central Nervous System
  • Findings: There is a solid hyperdense mass in the midline of the posterior fossa. It seems intimately related in the inferior vermis, abutting in the floor of the fourth ventricle and extending through the foramen magnum. The mass has homogenous enhancement with no diffusion restriction. There are prominent flow voids within the tumor. I note that the tumor is hyperdense on a non-contrast CT. Mild hydrocephalus. The remainder of the brain is unremarkable.
Date Published: 22nd Mar 2015
Source https://radiopaedia.org/cases/choroid-plexus-papilloma-5
Author RMH Neuropathology
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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