File:Fimmu-13-988536-g001.jpg
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English: The role of B cells in COVID-19 infection and re-infection. Naïve B cells are activated via the help of folliculat T (Tfh) cells after the invasion of SARS-CoV-2 virus. Following T-B interaction, B cells go through rapid proliferation and differentiation, producing pre-germinal center memory B cells (pre-GC MBCs) and short-lived plasma cells (SLPCs) producing early antibodies with low affinity. Other B cells enter the germinal center (GC) to increase antibody affinity by clonal expansion and somatic hypermutation (SHM), and change the structure through class-switching recombination (CSR), resulting in long-lived plasma cells (LLPCs) and memory B cells (MBCs). If challenged with a second invasion or vaccination, both pre-GC MBCs and MBCs generated after GC reactions differentiate into plasma cells or generate a second GC in a short period of time to produce high-affinity antibodies. Those B cells and antibodies secreted enter the blood circulation and peripheral tissues like mucosa to defend against viral infection and re-infection. Figure adapted from (18). |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468879/ |
Author | Shiru Chen, Fei Guan, Fabio Candotti, Kamel Benlagha, Niels Olsen Saraiva Camara, Andres A. Herrada, Louisa K. James, Jiahui Lei, Heather Miller, Masato Kubo, Qin Ning, Chaohong Liu |
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English: This file is licensed CC BY-NC 4.0
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current | 21:55, 11 May 2023 | 2,833 × 1,437 (324 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Shiru Chen, Fei Guan, Fabio Candotti, Kamel Benlagha, Niels Olsen Saraiva Camara, Andres A. Herrada, Louisa K. James, Jiahui Lei, Heather Miller, Masato Kubo, Qin Ning, Chaohong Liu from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468879/ with UploadWizard |
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