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English: Family pedigree, imaging, and genetic results. A: Brain magnetic resonance imaging (MRI) of the mother demonstrated prominent cerebellar atrophy, while the brainstem and middle cerebellar peduncles were relatively preserved (T2-weighted axial image). B: Brain MRI of the daughter showed diffuse cerebellar cortical atrophy (T2-weighted axial image). C: The patients’ family pedigree shows that only the proband and her daughter were affected. D: An electropherogram illustrated a missense mutation (c.1268G>A, p.R423H) of the KCNC3 gene in the mother, which verified the ataxia panel sequencing result of the daughter (heterozygous peaks, arrow).