File:Neurofibromatosis type 2 (Radiopaedia 45229-49302 H&E 1).png

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Summary:

Description
  • Radiopaedia case ID: 45229
  • Image ID: 22548562
  • Aux modality: H&E
  • Study findings: MICROSCOPIC DESCRIPTION: Sections show a tumor demonstrating histological features of both schwannoma and meningioma. The schwannoma component shows areas composed of short fascicles of tumor cells (Antoni A) with focal nuclear pallisading (Verocay bodies) and loose fibrillary areas (Antoni B). Tumor cells contain bland wavy nuclei with inconspicuous nucleoli. The meningioma component shows a moderately hypercellular meningioma with a well-developed syncytial architecture. Focal psammomatous calcifications are present. Tumor cells demonstrate uniform nuclear features. Focal dural attachment and bone invasion is noted. No mitoses, necrosis or brain invasion are seen. Immunohistochemical results confirm a S100+ schwannoma component andEMA+ meningioma component. The progesterone receptor immunostain is  positive within both components. DIAGNOSIS: Collision tumor (schwannoma and meningioma WHO grade I).
  • Modality: Pathology
  • System: Spine
  • Findings: Multiple meningiomas: right frontal parafalcine, right parietal convexity, left trigone, left sphenoidal wing meningioma, and left cerebellar convexity. Bilateral acoustic neuromas.
Date Published: 19th May 2016
Source https://radiopaedia.org/cases/neurofibromatosis-type-2-6
Author Bruno Di Muzio
Permission
(Permission-reusing-text)		 http://creativecommons.org/licenses/by-nc-sa/3.0/

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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)

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current12:41, 8 August 2021Thumbnail for version as of 12:41, 8 August 2021960 × 720 (1.6 MB)Fæ (talk | contribs)Radiopaedia project rID:45229 (thread B) (batch #25450-1 A1)

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