File:PMC3172311 pone.0024925.g001.png
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PMC3172311_pone.0024925.g001.png (426 × 594 pixels, file size: 154 KB, MIME type: image/png)
Summary
Description |
English: pone-0024925-g001: The mammalian Arg/N-end rule pathway and missense mutations in human UBR1 that underlie specific cases of the Johanson-Blizzard syndrome (JBS).(A) The mammalian N-end rule pathway. N-terminal residues are indicated by single-letter abbreviations for amino acids. Yellow ovals denote the rest of a protein substrate. ‘Primary’, ‘secondary’ and ‘tertiary’ denote mechanistically distinct subsets of destabilizing N-terminal residues (see Introduction). C* denotes oxidized Cys, either Cys-sulfinate or Cys-sulfonate. MetAPs, Met-aminopeptidases. (B) Single-residue mutations in the UBR1 proteins of JBS patients #1 and #2. The positions of mutant residues are indicated both for the original mutations in human UBR1 and for their mimics in S. cerevisiae. (C) Same as in B but the mutation in UBR1 of patient #3 (see Results). |
Date | |
Source | https://openi.nlm.nih.gov/detailedresult?img=PMC3172311_pone.0024925.g001&query=&req=4 |
Author | Hwang CS, Sukalo M, Batygin O, Addor MC, Brunner H, Aytes AP, Mayerle J, Song HK, Varshavsky A, Zenker M |
Licensing
English: This file is licensed CC BY-NC 4.0
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current | 20:02, 1 January 2023 | 426 × 594 (154 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Hwang CS, Sukalo M, Batygin O, Addor MC, Brunner H, Aytes AP, Mayerle J, Song HK, Varshavsky A, Zenker M from https://openi.nlm.nih.gov/detailedresult?img=PMC3172311_pone.0024925.g001&query=&req=4 with UploadWizard |
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