File:PMC3900397 pone.0084763.g006.png
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PMC3900397_pone.0084763.g006.png (512 × 415 pixels, file size: 180 KB, MIME type: image/png)
Summary
Description |
English: pone-0084763-g006: Model for changes in epithelial glucose handling in response to N. brasiliensis infection.(1) Infection induces a STAT6-dependent increase in mucosal permeability and (2) recruitment of alternatively activated macrophages (M2). (3) There is a M2-dependent inhibition of epithelial SGLT1 activity and M2-independent down-regulation of GLUT2. (4) This stresses the cell leading to activation of HIF-1α and up-regulation of the constitutive insulin-dependent GLUT1. This transporter serves as the major mechanism for glucose entry into the cell. Thus, parasitic nematode infection results in a “lean” epithelial phenotype as a result of a shift from insulin-dependent to insulin-independent glucose transporters. The increased permeability (1) enhances the contribution of paracellular absorption of glucose to maintain body weight during infection. |
Date | |
Source | https://openi.nlm.nih.gov/detailedresult?img=PMC3900397_pone.0084763.g006&query=Nematode%20infection&it=xg&req=4&npos=1 |
Author | Notari L, Riera DC, Sun R, Bohl JA, McLean LP, Madden KB, van Rooijen N, Vanuytsel T, Urban JF, Zhao A, Shea-Donohue T |
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{{subst:Custom license marker added by UW}} https://creativecommons.org/licenses/publicdomain/ Copyright-Only Dedication* (based on United States law) or Public Domain Certification
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current | 15:59, 2 February 2023 | 512 × 415 (180 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Notari L, Riera DC, Sun R, Bohl JA, McLean LP, Madden KB, van Rooijen N, Vanuytsel T, Urban JF, Zhao A, Shea-Donohue T from https://openi.nlm.nih.gov/detailedresult?img=PMC3900397_pone.0084763.g006&query=Nematode%20infection&it=xg&req=4&npos=1 with UploadWizard |
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