File:TCRM-84151-F02.jpg

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English: Figure 2 Olodaterol: mechanism of bronchodilating action. Notes: Olodaterol persistently binds with high affinity and selectivity to β2-adrenergic receptor (β2-AR), thus forming a very stable ternary complex, also including G stimulatory (Gs) protein. The subsequent, long-lasting stimulation of adenylyl cyclase (AC) and sustained increase in the intracellular concentration of second messenger cyclic AMP (cAMP) are responsible for activation of cAMP-dependent protein kinase A (PKA). PKA phosphorylates several targets involved in inhibition of Ca2+ release, as well as in sequestration of Ca2+ into intracellular stores.
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Source https://www.dovepress.com/pharmacologic-rationale-underlying-the-therapeutic-effects-of-tiotropi-peer-reviewed-fulltext-article-TCRM
Author Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese,Rosa Terracciano, Nicola Lombardo, Rosario Maselli
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current18:35, 2 January 2024Thumbnail for version as of 18:35, 2 January 20241,129 × 553 (51 KB)Ozzie10aaaa (talk | contribs)crop
18:31, 2 January 2024Thumbnail for version as of 18:31, 2 January 20241,129 × 666 (208 KB)Ozzie10aaaa (talk | contribs)Uploaded a work by Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese,Rosa Terracciano, Nicola Lombardo, Rosario Maselli from https://www.dovepress.com/pharmacologic-rationale-underlying-the-therapeutic-effects-of-tiotropi-peer-reviewed-fulltext-article-TCRM with UploadWizard

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