File:TCRM-84151-F02 (cropped).jpg
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Summary
| Description |
English: Figure 2 Olodaterol: mechanism of bronchodilating action.
Notes: Olodaterol persistently binds with high affinity and selectivity to β2-adrenergic receptor (β2-AR), thus forming a very stable ternary complex, also including G stimulatory (Gs) protein. The subsequent, long-lasting stimulation of adenylyl cyclase (AC) and sustained increase in the intracellular concentration of second messenger cyclic AMP (cAMP) are responsible for activation of cAMP-dependent protein kinase A (PKA). PKA phosphorylates several targets involved in inhibition of Ca2+ release, as well as in sequestration of Ca2+ into intracellular stores. |
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| Date | ||||
| Source | https://www.dovepress.com/pharmacologic-rationale-underlying-the-therapeutic-effects-of-tiotropi-peer-reviewed-fulltext-article-TCRM | |||
| Author | Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese,Rosa Terracciano, Nicola Lombardo, Rosario Maselli | |||
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| current | 08:20, 5 January 2024 | | 849 × 547 (50 KB) | Doc James (talk | contribs) | File:TCRM-84151-F02.jpg cropped 25 % horizontally, 1 % vertically using CropTool with precise mode. |
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