File:Gr1 (1).jpg
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Gr1_(1).jpg (743 × 544 pixels, file size: 49 KB, MIME type: image/jpeg)
Summary
Description |
English: Intracellular tumorigenic signaling pathway of neurofibromin and mechanism of action of MEK inhibitors. Neurofibromin promotes the conversion of active GTP-bound RAS to the inactive GDP-bound conformation (left). Loss of neurofibromin increases RAS activity and consequently the signaling cascade of the MEK/ERK pathway. MEK inhibitors (selumetinib, mirdametinib, trametinib, and binimetinib) inhibit this protein and block the MAPK signaling cascade (right). ERK, extracellular signal-regulated kinase; GDP, guanidine diphosphate; GRB2, growth factor receptor-bound protein 2; GTP, guanidine triphosphate; MAPK, mitogen-activated protein kinase; MEK, MAPK/extracellular-signal-regulated kinase; NF1, neurofibromin; Raf, serine/threonine-protein kinase; SOS, son of sevenless. |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363824/ |
Author | Solares I, Viñal D, Morales-Conejo M, Rodriguez-Salas N, Feliu J. |
Other-versions | {{{category}}} |
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English: This file is licensed CC BY-NC-ND 4.0
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current | 18:23, 11 March 2024 | 743 × 544 (49 KB) | Ozzie10aaaa (talk | contribs) | adjust | |
18:03, 11 March 2024 | 743 × 544 (151 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Solares I, Viñal D, Morales-Conejo M, Rodriguez-Salas N, Feliu J. from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363824/ with UploadWizard |
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