File:Gr1 (1) (cropped).jpg
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Gr1_(1)_(cropped).jpg (594 × 543 pixels, file size: 44 KB, MIME type: image/jpeg)
Summary
Description |
English: Intracellular tumorigenic signaling pathway of neurofibromin and mechanism of action of MEK inhibitors. Neurofibromin promotes the conversion of active GTP-bound RAS to the inactive GDP-bound conformation (left). Loss of neurofibromin increases RAS activity and consequently the signaling cascade of the MEK/ERK pathway. MEK inhibitors (selumetinib, mirdametinib, trametinib, and binimetinib) inhibit this protein and block the MAPK signaling cascade (right). ERK, extracellular signal-regulated kinase; GDP, guanidine diphosphate; GRB2, growth factor receptor-bound protein 2; GTP, guanidine triphosphate; MAPK, mitogen-activated protein kinase; MEK, MAPK/extracellular-signal-regulated kinase; NF1, neurofibromin; Raf, serine/threonine-protein kinase; SOS, son of sevenless. |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363824/ |
Author | Solares I, Viñal D, Morales-Conejo M, Rodriguez-Salas N, Feliu J. |
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English: This file is licensed CC BY-NC-ND 4.0
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 10:39, 12 March 2024 | 594 × 543 (44 KB) | Doc James (talk | contribs) | File:Gr1 (1).jpg cropped 20 % horizontally, < 1 % vertically using CropTool with precise mode. |
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