File:Journal of Neurochemistry - 2023 - Pertile - Vitamin D A potent regulator of dopaminergic neuron differentiation and.pdf
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Journal_of_Neurochemistry_-_2023_-_Pertile_-_Vitamin_D_A_potent_regulator_of_dopaminergic_neuron_differentiation_and.pdf (0 × 0 pixels, file size: 2.55 MB, MIME type: application/pdf)
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English: Vitamin D has been identified as a key factor in dopaminergic neurogenesis and differentiation. Consequently, developmental vitamin D (DVD) deficiency has been linked to disorders of abnormal dopamine signalling with a neurodevelopmental basis such as schizophrenia. Here we provide further evidence of vitamin D's role as a mediator of dopaminergic development by showing that it increases neurite outgrowth, neurite branching, presynaptic protein re-distribution, dopamine production and functional release in various in vitro models of developing dopaminergic cells including SH-SY5Y cells, primary mesencephalic cultures and mesencephalic/striatal explant co-cultures. This study continues to establish vitamin D as an important differentiation agent for developing dopamine neurons, and now for the first time shows chronic exposure to the active vitamin D hormone increases the capacity of developing neurons to release dopamine. This study also has implications for understanding mechanisms behind the link between DVD deficiency and schizophrenia. |
Date | |
Source | https://onlinelibrary.wiley.com/doi/10.1111/jnc.15829 |
Author | Renata Aparecida Nedel Pertile, Rachel Brigden, Vanshika Raman, Xiaoying Cui, Zilong Du, Darryl Eyles |
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English: This file is licensed CC BY-NC 4.0
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current | 16:23, 28 May 2023 | 0 × 0 (2.55 MB) | Koavf (talk | contribs) | Uploaded a work by Renata Aparecida Nedel Pertile, Rachel Brigden, Vanshika Raman, Xiaoying Cui, Zilong Du, Darryl Eyles from https://onlinelibrary.wiley.com/doi/10.1111/jnc.15829 with UploadWizard |
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