File:Tre-06-374-7522-1-v002.mp4

English: Segment 1. Brother at Presentation, Age 14.5. This video demonstrates irregular head tremor at rest and dystonia of the neck, upper limb, and trunk that increases during reaching. There is subtle intention tremor on finger-to-nose test. Gait is normal-based and steady, with generalized dystonia, particularly involving the right shoulder, left arm, and both lower limbs. Segment 2. Brother 18 Months after Presentation, Age 16. Eighteen months after presentation, the patient has a broad-based, unsteady gait and dysdiadochokinesia. Generalized dystonia is unchanged. Segment 3. Brother Post Treatment, Age 17. Treatment consisted of vitamin E (for 10 months) and trihexyphenidyl (for 2.5 years). The patient’s dysdiadochokinesia has improved significantly. He has residual upper limb dysmetria on the finger-to-nose test. Gait ataxia and generalized dystonia were unchanged.